Three New Selaginellin Derivatives from Selaginella pulvinata and Their α‐Glucosidase Inhibitory Activity

Abstract Three new selaginellin derivatives, selaginpulvilins V‐X ( 1–3 ), together with seven known analogs ( 4–10 ) were isolated from whole plants of Selaginella pulvinata . Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR‐ESI‐MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol‐trimmed skeleton. Biological evaluation showed that compounds 2 , 6 and 8 displayed moderate inhibition against α‐glucosidase with IC 50 values of 3.71, 2.04 and 4.00 μM, respectively.