衍生化
化学
卷柏属
IC50型
立体化学
植物
生物化学
有机化学
体外
生物
高效液相色谱法
作者
QinFeng Zhu,TianTian Luo,Qian Chen,BeiBei Gao,AiFen Zeng,JunLi Ao,GuoBo Xu,ShangGao Liao,Xun He
标识
DOI:10.1002/cbdv.202300109
摘要
Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR-ESI-MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol-trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α-glucosidase with IC50 values of 3.71, 2.04 and 4.00 μM, respectively.
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