Clinical study that preoperative intracavitary radiotherapy combined with neoadjuvant chemotherapy promotes apoptosis in IIa and IIb cervical cancer tissue

Objective: To study the effect of preoperative intracavitary radiotherapy combined with \nneoadjuvant chemotherapy on apoptosis in IIa and IIb cervical cancer tissue. Methods: \nPatients with IIa and IIb locally advanced cervical cancer who received preoperative auxiliary \ntherapy in our hospital between May 2013 and December 2016 were retrospectively analyzed \nand divided into adjuvant chemotherapy group, intracavitary radiotherapy group and combined \ntreatment group according to the different preoperative adjuvant therapies. Cervical cancer \ntissues were collected respectively during biopsy (before treatment) and during surgical \nexcision (after treatment) to extract RNA, and then fluorescence quantitative PCR kits were \nused to determine the expression of pro-apoptosis genes, anti-apoptosis genes and invasion \ngenes. Results: After treatment, SARI, Rab26, FHIT and eIF4E3 expression in cervical cancer \nlesions of three groups were significantly higher than those before treatment while serum \nCA125, TSGF and SCC-Ag levels as well as MRP8, MRP14, p38MAPK, ERK1/2 and c-myc \nexpression were significantly lower than those before treatment, and SARI, Rab26, FHIT and \neIF4E3 expression in cervical cancer lesions of combined treatment group were significantly \nhigher than those of adjuvant chemotherapy group and intracavitary radiotherapy group while \nserum CA125, TSGF and SCC-Ag levels as well as MRP8, MRP14, p38MAPK, ERK1/2 \nand c-myc expression were significantly lower than those of adjuvant chemotherapy group \nand intracavitary radiotherapy group. Conclusion: Preoperative intracavitary radiotherapy \ncombined with neoadjuvant chemotherapy can promote apoptosis in IIa and IIb cervical cancer \ntissue.