The impact of multidomain interventions on cognitive and physical function in older adults with subjective cognitive decline: a meta‑analysis and systematic review

Background: This study aimed to examine the efficacy of multidomain interventions compared to control and nutritional interventions in older adults with subjective cognitive decline (SCD). Four databases were searched for relevant literature. Methodology: PubMed, Embase, Cochrane Library, and Web of Science databases were searched for relevant studies. Randomized controlled trials that examined the effects of multidomain interventions on cognitive and physical function in older adults with SCD were included. Results: This study included six eligible studies with 1,767 participants. The results indicated that multidomain interventions significantly improved executive function and memory but did not significantly impact global cognition and physical performance compared to the control group. In addition, significant enhancements were observed in executive function and memory when compared to single nutritional interventions. Conclusions: The findings revealed that multidomain interventions could effectively improve executive function and memory in older adults with SCD. Further studies with robust designs, particularly those comparing single-domain interventions, are needed to investigate the effects and underlying mechanisms.