Enhancing Chiral Site Density in Covalent Organic Frameworks Enables Efficient SERS-Based Enantioselective Discrimination

, highlighting the effectiveness of the "two-in-one" strategy in amplifying chiral recognition. This work presents a generalizable approach for constructing high-performance chiral COF-based SERS substrates and advances the application of crystalline porous materials in enantiomeric analysis.