IFN‐α2b Modulates GATA3 Expression to Inhibit Proliferation and Promote Apoptosis in KSHV‐Infected Cells

Previous studies have established that interferon (IFN) can inhibit the occurrence and progression of various tumors, particularly those associated with viral infections. However, the specific molecular mechanisms underlying its effects remain a key research focus. This study aims to elucidate how interferon inhibits Kaposi's sarcoma (KS), ultimately to improve its therapeutic efficacy against this condition. The role of IFN-α2b in treatingKS has been extensively studied, especially regarding its antiviral properties and immune regulatory functions. In this study, we demonstrate that IFN-α2b suppresses LANA expression in KSHV-infected cells, thereby reducing cell proliferation and increasing apoptosis. Further investigation into the molecular mechanisms revealed that IFN-α2b enhances the expression of GATA3, and that overexpression of GATA3 inhibits the phosphorylation of STAT5B. In summary, IFN-α2b exerts its inhibitory effects on KS by regulating GATA3 expression. Additionally, exploring the interactions between IFN-α2b and other molecules may uncover more complex tumor-suppressing mechanisms.