Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans

Hamigerans, a class of diterpenoid natural products isolated from marine sponge Hamigera tarangaensis, are characterized by distinctive 6–6–5 or 6–7–5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013. Our goal for this Review is to provide new insights for future research on this class of marine natural products.