An Efficient Route to Annulated Pyrrolo[2,1‐a]Isoquinoline‐3‐Carboxamide Derivatives via Nitrogen Ylides

ABSTRACT Treatment of isoquinoline with some N,N ‐disubstituted α ‐bromoacetamide compounds afforded the corresponding isoquinolinium bromides having the electron‐rich carbazolyl, diphenylamino, and diisopropylamino moieties. The isoquinolinium salts were subjected to a heteroannulation process via a reaction with some dipolarophiles under basic medium to generate the corresponding pyrrolo[2,1‐ a ]isoquinoline‐3‐carboxamide derivatives via [3 + 2] cycloaddition reaction. The obtained compounds were characterized using the appropriate spectroscopic techniques.