化学
亚砜
动力学分辨率
产量(工程)
基质(水族馆)
对映体
对映体过量
分辨率(逻辑)
烷基
立体化学
酶
对映选择合成
有机化学
催化作用
人工智能
地质学
冶金
材料科学
海洋学
计算机科学
作者
Yuyan Zhao,Xu Jiang,Shihuan Zhou,Jin Tian,Pengyuan Yang,Yanli Chen,Quan Zhang,Xianlin Xu,Yong‐Zheng Chen,Jiawei Yang
摘要
Optically pure sulfoxides are noteworthy compounds that find wide applications in various industrial fields. Here, we report a methionine sulfoxide reductase B (MsrB) homologue that exhibits high enantioselectivity and broad substrate scope for the kinetic resolution of racemic (rac) sulfoxides. This MsrB homologue, named liMsrB, was identified from Limnohabitans sp. 103DPR2 and showed good activity together with enantioselectivity towards a series of aromatic, heteroaromatic, alkyl and thioalkyl sulfoxides. Chiral sulfoxides in the S configuration were prepared in approximately 50% yield and 92-99% enantiomeric excess through kinetic resolution at an initial substrate concentration of up to 90 mM (11.2 g L-1). This study presents an efficient route for the enzymatic preparation of (S)-sulfoxides through kinetic resolution.
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