单核细胞增多症
噬血细胞性淋巴组织细胞增多症
爱泼斯坦-巴尔病毒
小RNA
爱泼斯坦-巴尔病毒感染
免疫学
病毒
溶解循环
生物
病毒学
医学
癌症研究
疾病
基因
病理
生物化学
作者
Wei‐Ting Wang,Yang Yun,Jiatong Zhang,Le Yi-Ning,Yonggang Wu,Yiyi Liu,Tu Yan-Jie
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2024-01-01
卷期号:24 (1): 2-13
被引量:1
标识
DOI:10.2174/1566524023666221118122005
摘要
Abstract: At present, timely and accurate diagnosis and effective treatment of Epstein- Barr Virus (EBV) infection-associated fever remain a difficult challenge. EBV encodes 44 mature microRNAs (miRNAs) that inhibit viral lysis, adjust inflammatory response, regulate cellular apoptosis, promote tumor genesis and metastasis, and regulate tumor cell metabolism. Herein, we have collected the specific expression data of EBV-miRNAs in EBV-related fevers, including infectious mononucleosis (IM), EBVassociated hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infection (CAEBV), and EBV-related tumors, and proposed the potential value of EBVmiRNAs as biomarkers to assist in the identification, diagnosis, and prognosis of EBVrelated fever, as well as therapeutic targets for drug development.
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