目标2
上睑下垂
炎症体
炎症
免疫系统
神经科学
促炎细胞因子
医学
免疫学
生物
作者
Rao Fu,Linna Zhao,Yuanshan Guo,Xiaoli Qin,Weiqing Xu,Xueqi Cheng,Yunsha Zhang,Shixin Xu
标识
DOI:10.1016/j.clim.2023.109881
摘要
Ischemic stroke (IS) is a significant global public health issue with a high incidence, disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging mechanisms occurs following ischemic brain injury. Inflammasomes are multiprotein complexes in the cytoplasm that modulate the inflammatory response by releasing pro-inflammatory cytokines and inducing cellular pyroptosis. Among these inflammasomes, the Absent in Melanoma 2 (AIM2) inflammasome shows the ability to detect a wide range of pathogen DNAs, thereby triggering an inflammatory response. Recent studies have indicated that the aberrant expression of AIM2 inflammasome in various cells is closely associated with the pathological processes of ischemic brain injury. This paper summarizes the expression and regulatory role of AIM2 in CNS and peripheral immune cells and discusses current therapeutic approaches targeting AIM2 inflammasome. These findings aim to serve as a reference for future research in this field.
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