褪黑素
骨关节炎
医学
氧化应激
疾病
炎症
治疗方法
生物信息学
不利影响
药理学
内科学
病理
生物
替代医学
作者
Zhilin Xiong,Guoxuan Peng,Jin Deng,Miaomiao Liu,Nuo Xu,Yong Zhuang,Hua Yang,Hong Sun
标识
DOI:10.3389/fimmu.2024.1331934
摘要
Osteoarthritis (OA) is a highly prevalent age-related musculoskeletal disorder that typically results in chronic pain and disability. OA is a multifactorial disease, with increased oxidative stress, dysregulated inflammatory response, and impaired matrix metabolism contributing to its onset and progression. The neurohormone melatonin, primarily synthesized by the pineal gland, has emerged as a promising therapeutic agent for OA due to its potential to alleviate inflammation, oxidative stress, and chondrocyte death with minimal adverse effects. The present review provides a comprehensive summary of the current understanding regarding melatonin as a promising pharmaceutical agent for the treatment of OA, along with an exploration of various delivery systems that can be utilized for melatonin administration. These findings may provide novel therapeutic strategies and targets for inhibiting the advancement of OA.
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