从长凳到床边
医学
偏头痛
降钙素基因相关肽
生物信息学
降钙素
重症监护医学
偏头痛
偏头痛治疗
神经科学
药理学
精神科
受体
内科学
神经肽
医学物理学
生物
作者
Anne Luise Haulund Vollesen,Jan Hoffmann,Håkan Ashina,Debbie L. Hay,Yadira Flores-Montanez,Thien Phu,Roberto De Icco,David W. Dodick
标识
DOI:10.1016/j.mayocp.2023.07.003
摘要
Migraine is a ubiquitous neurologic disorder that afflicts more than 1 billion people worldwide. Recommended therapeutic strategies include the use of acute and, if needed, preventive medications. During the past 2 decades, tremendous progress has been made in better understanding the molecular mechanisms underlying migraine pathogenesis, which in turn has resulted in the advent of novel medications targeting signaling molecule calcitonin gene-related peptide or its receptor. Here, we provide an update on the rational use of pharmacotherapies for migraine to facilitate more informed clinical decision-making. We then discuss the scientific discoveries that led to the advent of new medications targeting calcitonin gene-related peptide signaling. Last, we conclude with recent advances that are being made to identify novel drug targets for migraine.
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