肿瘤微环境
纳米载体
免疫原性
免疫系统
细胞外基质
癌症
癌症研究
转移
药物输送
医学
纳米技术
肿瘤细胞
材料科学
免疫学
生物
细胞生物学
内科学
作者
Cheng Peng,Yilin Xu,Jianzhong Wu,Donghai Wu,Lili Zhou,Xinhua Xia
摘要
Abstract: The tumor microenvironment (TME) plays an important role in various stages of tumor generation, metastasis, and evasion of immune monitoring and treatment. TME targeted therapy is based on TME components, related pathways or active molecules as therapeutic targets. Therefore, TME targeted therapy based on environmental differences between TME and normal cells has been widely studied. Biomimetic nanocarriers with low clearance, low immunogenicity, and high targeting have enormous potential in tumor treatment. This review introduces the composition and characteristics of TME, including cancer‑associated fibroblasts (CAFs), extracellular matrix (ECM), tumor blood vessels, non-tumor cells, and the latest research progress of biomimetic nanoparticles (NPs) based on TME. It also discusses the opportunities and challenges of clinical transformation of biomimetic nanoparticles. Keywords: nanoparticles, biomimetic delivery system, tumor therapy, cell membrane-coating
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