透明质酸
姜黄素
纳米医学
伤口愈合
炎症
生物利用度
活性氧
体内
药理学
化学
体外
医学
纳米技术
纳米颗粒
免疫学
生物化学
材料科学
生物
生物技术
解剖
作者
Shuai Wu,Li Zhu,Ning Sheng,Yuan Zhong,Kai Qu,Xian Qin,Kun Zhang,Guixue Wang,Da Sun,Wuquan Deng,Wei Wu
标识
DOI:10.1016/j.ijbiomac.2024.130249
摘要
Persistent over-oxidation, inflammation and bacterial infection are the primary reasons for impaired wound repairing in diabetic patients. Therefore, crucial strategies to promote diabetic wound repairing involve suppressing the inflammatory response, inhibiting bacterial growth and decreasing reactive oxygen species (ROS) within the wound. In this work, we develop a multifunctional nanomedicine (HA@Cur/Cu) designed to facilitate the repairing process of diabetic wound. The findings demonstrated that the synthesized infinite coordination polymers (ICPs) was effective in enhancing the bioavailability of curcumin and improving the controlled drug release at the site of inflammation. Furthermore, in vitro and in vivo evaluation validate the capacity of HA@Cur/Cu to inhibit bacterial growth and remove excess ROS and inflammatory mediators, thereby significantly promoting the healing of diabetic wound in mice. These compelling findings strongly demonstrate the enormous promise of this multifunctional nanomedicine for the treatment of diabetic wound.
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