可药性
广告
药理学
急性肾损伤
肾
化学
医学
癌症研究
药品
生物化学
内科学
基因
内分泌学
作者
Ping Yu,Tanwei Gu,Yueyang Rao,Weimin Liang,Xi Zhang,Huanguo Jiang,Jindi Lu,Jianglian She,Jianmin Guo,Wei Yang,Yonghong Liu,Yingfeng Tu,Lan Tang,Xuefeng Zhou
标识
DOI：10.1016/j.apsb.2024.03.005
摘要
Insufficient therapeutic strategies for acute kidney injury (AKI) necessitate precision therapy targeting its pathogenesis. This study reveals the new mechanism of the marine-derived anti-AKI agent, piericidin glycoside S14, targeting peroxiredoxin 1 (PRDX1). By binding to Cys83 of PRDX1 and augmenting its peroxidase activity, S14 alleviates kidney injury efficiently in
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