Isolation, characterization, and circulation sphere of a filovirus in fruit bats

丝虫科 分离(微生物学) 天然水库 病毒学 生物 系统发育树 动物 冠状病毒 进化生物学 组织向性 病毒 向性 遗传学 微生物学 2019年冠状病毒病(COVID-19) 基因 病毒性疾病 副粘病毒科 医学 传染病(医学专业) 病理 疾病
作者
Biao He,Tingsong Hu,Xiaomin Yan,Yanhui Pa,Yuhang Liu,Yang Liu,Nan Li,Jing Wang,Hailin Zhang,Yonghua Liu,Jun Chai,Yue Sun,Shijiang Mi,Yan Liu,Yi Le,Zhongzhong Tu,Yiyin Wang,Sheng Sun,Ye Feng,Wendong Zhang,Huanyun Zhao,Bo-fang Duan,Wenjie Gong,Fuqiang Zhang,Changchun Tu
出处
期刊:Proceedings of the National Academy of Sciences of the United States of America [National Academy of Sciences]
卷期号:121 (7) 被引量:1
标识
DOI:10.1073/pnas.2313789121
摘要

Bats are associated with the circulation of most mammalian filoviruses (FiVs), with pathogenic ones frequently causing deadly hemorrhagic fevers in Africa. Divergent FiVs have been uncovered in Chinese bats, raising concerns about their threat to public health. Here, we describe a long-term surveillance to track bat FiVs at orchards, eventually resulting in the identification and isolation of a FiV, Dehong virus (DEHV), from Rousettus leschenaultii bats. DEHV has a typical filovirus-like morphology with a wide spectrum of cell tropism. Its entry into cells depends on the engagement of Niemann-Pick C1, and its replication is inhibited by remdesivir. DEHV has the largest genome size of filoviruses, with phylogenetic analysis placing it between the genera Dianlovirus and Orthomarburgvirus , suggesting its classification as the prototype of a new genus within the family Filoviridae . The continuous detection of viral RNA in the serological survey, together with the wide host distribution, has revealed that the region covering southern Yunnan, China, and bordering areas is a natural circulation sphere for bat FiVs. These emphasize the need for a better understanding of the pathogenicity and potential risk of FiVs in the region.
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