蛋白质组学
质谱法
视网膜脱离
视网膜
黄斑变性
视网膜
细胞外小泡
管道(软件)
蛋白质组
化学
眼科
医学
生物信息学
计算机科学
生物
色谱法
细胞生物学
生物化学
神经科学
基因
程序设计语言
作者
Sarah R. Weber,Nick Carruthers,Chris Gates,Yuanjun Zhao,Jeffrey M. Sundstrom
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 157-167
标识
DOI:10.1007/978-1-0716-3255-0_11
摘要
Retinal diseases like diabetic retinopathy and age-related macular degeneration affect millions of individuals worldwide and often lead to vision loss. Vitreous fluid abuts the retina, is accessible for sampling, and contains many proteins related to retinal disease. Therefore, analysis of vitreous is an important tool for studying retinal disease. Because it is rich in proteins and extracellular vesicles, mass spectrometry-based proteomics is an excellent method for vitreous analysis. Here, we discuss important variables to consider when performing vitreous proteomics via mass spectrometry.
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