氧化应激
癌细胞
细胞生物学
胱氨酸
程序性细胞死亡
背景(考古学)
细胞内
癌症研究
化学
癌症
生物
细胞凋亡
生物化学
酶
遗传学
半胱氨酸
古生物学
作者
Yizhong Yan,Hongqi Teng,Qinglei Hang,Lavanya Kondiparthi,Guang Lei,Amber Horbath,Xiaoguang Liu,Chao Mao,Shiqi Wu,Zhuang Li,M. James You,Masha V. Poyurovsky,Li Ma,Kellen L. Olszewski,Boyi Gan
标识
DOI:10.1038/s41467-023-39401-9
摘要
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surprising finding that, whereas moderate overexpression of SLC7A11 is beneficial for cancer cells treated with H2O2, a common oxidative stress inducer, its high overexpression dramatically increases H2O2-induced cell death. Mechanistically, high cystine uptake in cancer cells with high overexpression of SLC7A11 in combination with H2O2 treatment results in toxic buildup of intracellular cystine and other disulfide molecules, NADPH depletion, redox system collapse, and rapid cell death (likely disulfidptosis). We further show that high overexpression of SLC7A11 promotes tumor growth but suppresses tumor metastasis, likely because metastasizing cancer cells with high expression of SLC7A11 are particularly susceptible to oxidative stress. Our findings reveal that SLC7A11 expression level dictates cancer cells' sensitivity to oxidative stress and suggests a context-dependent role for SLC7A11 in tumor biology.
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