2型糖尿病
信号转导
重新调整用途
胰岛素抵抗
生物信息学
机制(生物学)
疾病
医学
生物
2型糖尿病
糖尿病
神经科学
内科学
内分泌学
遗传学
哲学
生态学
认识论
作者
Rong Cao,Huimin Tian,Yanbo Zhang,Geng Li,Haixia Xu,Guocheng Rao,Yan Tian,Xianghui Fu
出处
期刊:MedComm
[Wiley]
日期:2023-06-01
卷期号:4 (3)
被引量:5
摘要
Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including vascular, visual, neurological, kidney, and liver diseases. Moreover, recent data suggest a mutual interplay between T2DM and Corona Virus Disease 2019 (COVID-19). T2DM is characterized by insulin resistance (IR) and pancreatic β cell dysfunction. Pioneering discoveries throughout the past few decades have established notable links between signaling pathways and T2DM pathogenesis and therapy. Importantly, a number of signaling pathways substantially control the advancement of core pathological changes in T2DM, including IR and β cell dysfunction, as well as additional pathogenic disturbances. Accordingly, an improved understanding of these signaling pathways sheds light on tractable targets and strategies for developing and repurposing critical therapies to treat T2DM and its complications. In this review, we provide a brief overview of the history of T2DM and signaling pathways, and offer a systematic update on the role and mechanism of key signaling pathways underlying the onset, development, and progression of T2DM. In this content, we also summarize current therapeutic drugs/agents associated with signaling pathways for the treatment of T2DM and its complications, and discuss some implications and directions to the future of this field.
科研通智能强力驱动
Strongly Powered by AbleSci AI