Dietary intake assessment of known and unknown organophosphate esters (OPEs) in foodstuffs via high-resolution mass spectrometry

We applied an integrated target, suspect, and non-target screening strategy to analyze known and unknown organophosphate esters (OPEs) in 107 foodstuffs collected from Nanjing City, China, in 2020. Twelve out of 19 target OPEs were detectable in at least one of the analyzed samples. Among the nine food categories, meat samples were contaminated the most severely with a mean ΣOPEs concentration of 68.5 ng/g wet weight (ww). In most food categories, tris(2,4-di-tert-butylphenyl) phosphate was the predominant OPE with a mean concentrations of 2.26 ng/g ww. In the food extract samples, suspect and non-target analysis identified other 6 suspect OPEs and 1 non-target OPE, of which two were fully identified as tri-m-cresyl phosphate, and trihexyl phosphate. Based on the measured OPE concentrations, we estimated the daily per capita dietary intakes of ΣOPEs for Nanjing residents to be 423 ng/kg bw/day, which is less than the reference dosage value of each OPE. Collectively, this study provides new information regarding the comprehensive identification of OPEs in foodstuffs, and revealed the importance of dietary risk assessment of this emerging class of contaminants.