Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan

医学 内窥镜检查 临床终点 内科学 窄带成像 随机对照试验 癌症 胃肠病学 外科
作者
Yoshinobu Yamamoto,Nobuaki Yoshida,Tomonori Yano,Takahiro Horimatsu,Noriya Uedo,Noboru Kawata,Hiromitsu Kanzaki,Shinichiro Hori,Kenshi Yao,Seiichiro Abe,Chikatoshi Katada,Chizu Yokoi,Ken Ohata,Hisashi Doyama,Kenichi Yoshimura,Hideki Ishikawa,Manabu Muto
出处
期刊:JAMA network open [American Medical Association]
卷期号:5 (8): e2227667-e2227667 被引量:3
标识
DOI:10.1001/jamanetworkopen.2022.27667
摘要

Single endoscopic examination often misses early gastric cancer (GC), even when both high-definition white light imaging and narrow-band imaging are used. It is unknown whether new GC can be detected approximately 1 year after intensive index endoscopic examination.To examine whether new GC can be detected approximately 1 year after intensive index endoscopic examination using both white light and narrow-band imaging.This case-control study was a preplanned secondary analysis of a randomized clinical trial involving 4523 patients with a high risk of GC who were enrolled between October 1, 2014, and September 22, 2017. Data were analyzed from December 26, 2019, to April 21, 2021. Participants in the clinical trial received index endoscopy to detect early GC via 2 examinations of the entire stomach using white light and narrow-band imaging. The duration of follow-up was 15 months. The secondary analysis included 107 patients with newly detected GC (case group) and 107 matched patients without newly detected GC (control group) within 15 months after index endoscopy.Surveillance endoscopy was scheduled between 9 and 15 months after index endoscopy. If new lesions suspected of being early GC were detected during surveillance endoscopy, biopsies were obtained to confirm the presence of cancer.The primary end point was the rate of new GC detected within 15 months after index endoscopy. The main secondary end point was identification of risk factors associated with new GC detected within 15 months after index endoscopy.Among 4523 patients (mean [SD] age, 70.6 [7.5] years; 3527 men [78.0%]; all of Japanese ethnicity) enrolled in the clinical trial, 4472 received index endoscopy; the rate of early GC detected on index endoscopy was 3.0% (133 patients). Surveillance endoscopy was performed in 4146 of 4472 patients (92.7%) who received an index endoscopy; the rate of new GC detected within 15 months after index endoscopy was 2.6% (107 patients). Among 133 patients for whom early GC was detected during index endoscopy, 110 patients (82.7%) received surveillance endoscopy within 15 months after index endoscopy; the rate of newly detected GC was 10.9% (12 patients). For the secondary analysis of risk factors associated with newly detected GC, characteristics were well balanced between the 107 patients included in the case group vs the 107 patients included in the matched control group (mean [SD] age, 71.7 [7.2] years vs 71.8 [7.0] years; 94 men [87.9%] in each group; 82 patients [76.6%] vs 87 patients [81.3%] with a history of gastric neoplasm). Multivariate analysis revealed that the presence of open-type atrophic gastritis (odds ratio, 6.00; 95% CI, 2.25-16.01; P < .001) and early GC detection by index endoscopy (odds ratio, 4.67; 95% CI, 1.08-20.21; P = .04) were independent risk factors associated with new GC detection.In this study, the rate of new GC detected by surveillance endoscopy approximately 1 year after index endoscopy was similar to that of early GC detected by index endoscopy. These findings suggest that 1-year surveillance is warranted for patients at high risk of GC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
东西南北完成签到,获得积分10
1秒前
2秒前
茅十八完成签到,获得积分10
6秒前
7秒前
李健的小迷弟应助眼药水采纳,获得10
9秒前
沐沐1003完成签到,获得积分10
10秒前
17秒前
ericxu发布了新的文献求助10
21秒前
23秒前
隐形曼青应助gaopeng采纳,获得10
24秒前
小南完成签到,获得积分10
24秒前
买菜市民熊先生完成签到,获得积分10
24秒前
25秒前
儒雅雅琴完成签到,获得积分10
27秒前
小郭子完成签到,获得积分10
28秒前
眼药水发布了新的文献求助10
29秒前
悦耳曼凝完成签到 ,获得积分10
32秒前
Mercury完成签到 ,获得积分10
34秒前
向阳葵完成签到 ,获得积分10
34秒前
ChatGPT完成签到,获得积分10
37秒前
科研通AI2S应助ChatGPT采纳,获得10
40秒前
41秒前
只有辣椒没有油完成签到 ,获得积分10
45秒前
小乙猪完成签到 ,获得积分0
49秒前
一一完成签到,获得积分10
59秒前
科目三应助科研通管家采纳,获得10
1分钟前
华仔应助科研通管家采纳,获得10
1分钟前
loey完成签到,获得积分10
1分钟前
诸葛亮火烧盘丝洞完成签到 ,获得积分10
1分钟前
可爱的梦松完成签到,获得积分10
1分钟前
李健应助开朗的曼越梅采纳,获得10
1分钟前
1分钟前
伶俐楷瑞发布了新的文献求助10
1分钟前
无有发布了新的文献求助10
1分钟前
XHH完成签到 ,获得积分10
1分钟前
1分钟前
czj完成签到,获得积分10
1分钟前
1分钟前
玉崟完成签到 ,获得积分10
1分钟前
HSJ完成签到 ,获得积分10
1分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2546270
求助须知:如何正确求助?哪些是违规求助? 2175702
关于积分的说明 5600512
捐赠科研通 1896445
什么是DOI,文献DOI怎么找? 946285
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503557