Intermittent versus Daily Eltrombopag Dosage Protocols for the Treatment of Primary Immune Thrombocytopenia: Real-Life Experience

Tamer A Elbedewy,1 Mohamed A Elsebaey,1 Reem A Elkholy,2 Dina M Tahoon,2 Samah A Elshweikh1 1Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Medical Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, EgyptCorrespondence: Tamer A ElbedewyDepartment of Internal Medicine, Tanta University, Tanta, EgyptTel + 020-01094680720Email tamer.elbedawi@med.tanta.edu.egIntroduction/Aim: Eltrombopag is recommended for the treatment of refractory immune thrombocytopenia (ITP). Based on its half-life, it may be practical to use an intermittent dosage. Our aim was to compare the effectiveness and safety of intermittent vs daily eltrombopag dosage protocols for the treatment of primary ITP refractory to prior therapies.Patients and Methods: This was a retrospective study, and 34 adult primary ITP patients refractory to prior therapies were included in our analysis. Eltrombopag was used in this study. The patients were divided into daily eltrombopag dosage and intermittent eltrombopag dosage groups. Eltrombopag effectiveness was assessed regarding platelet count and bleeding resolution. Safety was assessed via adverse events reporting.Results: In the daily eltrombopag dosage group, overall response (OR), complete response (CR), partial response (PR), and relapse rates were 69.23%, 53.85%, 15.38%, and 30.77%, respectively. In the intermittent eltrombopag dosage group, OR, CR, PR, and relapse rates were 68.75%, 50%, 18.75%, and 31.25%, respectively. Comparison between daily and intermittent eltrombopag dosage groups as regards CR, PR, relapse, relapse-free survival and adverse events showed insignificant differences.Conclusion: Intermittent eltrombopag dosage is safe and effective in patients with ITP refractory to prior therapies and comparable to the daily eltrombopag dosage.Keywords: immune thrombocytopenia, eltrombopag, daily dosage, intermittent dosage, effectiveness, safety