Therapeutic mechanisms of ellagic acid for inflammation and related conditions

Ellagic acid, a plant-based polyphenolic active compound from a wide range of sources, has multiple effects against inflammation and oxidative stress. It is easily accepted and taken for its subtle therapeutic effects due to its plant-based nature. Ellagic acid exerts a positive effect on the negative effects of inflammation by modulating inflammatory signals or by activating/inhibiting inflammatory cytokines (IL-1β, IL-6, TNFα, etc.). Since, at present, systemic chronic inflammation (SCI) is a serious cause of death worldwide, there is much research evidence that ellagic acid has a powerful therapeutic effect on inflammation, as well as on conditions such as diabetes, cancer, and depression, which are accompanied by inflammation at the onset. This review aims to explain the healing mechanism of ellagic acid for inflammation and its related conditions, as ellagic acid is attracting increasing attention from people and society as a future important drug that can cure inflammation.