Research Progress of Ferroptosis in Septic Organ Damage

Sepsis is one of the main causes of death in severely infected patients, and the complexity of its pathogenesis increases the difficulty of clinical treatment. Ferroptosis is a new cell death mode discovered in recent years, which is closely related to the severity of sepsis. Research has found that iron accumulation can not only serve as an effective indicator for evaluating the severity of sepsis in patients, but also predict the prognosis of sepsis patients. In recent years, studies have pointed out that severe Ferroptosis exists in the body after sepsis, and inhibiting Ferroptosis is expected to become a new target for sepsis treatement. This article summarizes the evidence of Ferroptosis in sepsis organ injury, and provides new ideas for further research and treatment of sepsis.