Investigation of the Status of Epidemiology, Pathophysiology, Virology, Clinical Symptoms, Diagnosis, Prevention, Treatment and Classification of Ebola Virus Disease (EVD): A Systematic Review

Background and Objectives: Ebola Virus Disease (EVD) is one of the deadliest viral diseases in history, rapidly spreading to other parts of the world. Due to frequent travel, the popularity of tourism, public international contacts, and imported goods, Ebola is consid-ered a threat to people around the world. The present study was conducted with the aim of determining the status of epidemiology, pathophysiology, virology, clinical symptoms, diag-nosis, prevention, treatment, and classification of EVD. Methods: This systematic review was conducted in the spring of 2024 by searching English articles using desired keywords in PubMed, Google Scholar, ISC, Scopus, and Web of Sci-ence databases without time limits. The search strategy was based on the PRISMA 2020 statement. Results: Frequent outbreaks of EVD have caused numerous deaths and complications. Since the virus may lead to a pandemic, its prevention is of great importance due to its high potential to cause a significant physical and economic burden. Conclusion: Hence, there is an urgent need to conduct clinical trials on EVD to develop possible treatments and strategies to prevent any further outbreaks of the disease. Keywords: Ebola Virus Disease (EVD), transmission, epidemiology, pathophysiology, virology, symptoms, diagnosis, prevention, treatment.