Stimulus-responsive starch-based nanocapsules for targeted delivery and antibacterial applications

Polysaccharide materials have attracted a widespread interest in the biomedical materials field due to their non-toxic, biocompatible and biodegradable properties. In this research, starch was modified with chloroacetic acid, folic acid (FA) and thioglycolic acid and then starch-based nanocapsules loaded with curcumin (FA-RSNCs@CUR) were prepared by the convenient oxidation method. The nanocapsules were prepared with stable particle size distribution of 100 nm. In the drug release test simulating the tumor microenvironment in vitro, the cumulative CUR release rate at 12 h was 85.18 %. Due to FA and FA receptor mediation, it only took 4 h for FA-RSNCs@CUR to achieve internalization by HeLa cells. In addition, cytotoxicity confirmed that starch-based nanocapsules have good biocompatibility as well as protection of normal cells in vitro. And FA-RSNCs@CUR showed certain antibacterial properties in vitro. Therefore, FA-RSNCs@CUR has good potential for future applications in food preservation and wound dressing, and so on.