Notch信号通路
信号转导
小RNA
癌症研究
生物
槽口1
癌症
细胞生物学
药理学
化学
生物化学
基因
遗传学
作者
Atul Kumar Singh,Shashank Kumar
标识
DOI:10.1080/10286020.2023.2202854
摘要
Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the chemotherapy but none got clinical approval due to severe toxicity in patients. Flavonoids inhibit NSP by inhibiting notch receptor cleavage and/or inhibiting transcriptional regulation by Notch intracellular domain (NICD). Interestingly, some flavonoids are reported to inhibit NSP by mediating the microRNA expression. NSP inhibitory flavonoid(s) in combination with standard therapy is might be an effective strategy in cancer treatment.
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