酒渣鼻
槲皮素
炎症
血管生成
药理学
体内
ICAM-1
免疫系统
哈卡特
医学
癌症研究
体外
生物
免疫学
细胞粘附分子
生物化学
皮肤病科
痤疮
抗氧化剂
生物技术
作者
Xin Meng,Yangfan Li,Wei Fan,Tao Li,Ben Wang,Qian Wang,Juan Long,Hongfu Xie,Yiya Zhang,Ji Li
标识
DOI:10.1016/j.lfs.2024.122675
摘要
Rosacea is an inflammatory skin disease with immune and vascular dysfunction. Although there are multiple treatment strategies for rosacea, the clinical outcomes are unsatisfactory. Combining transcriptome data and the Connectivity Map database quercetin was identified as a novel candidate for rosacea. Next, the therapeutic efficacy of quercetin was substantiated through proteomic analyses, in vivo experiments, and in vitro assays. Additionally, the utilization of DARTS, molecular docking and experimental verification revealed the therapeutic mechanisms of quercetin. Treatment with quercetin resulted in the following effects: (i) it effectively ameliorated rosacea-like features by reducing immune infiltration and angiogenesis; (ii) it suppressed the expression of inflammatory mediators in HaCaT cells and HDMECs; (iii) it interacted with p65 and ICAM-1 directly, and this interaction resulted in the repression of NF-kB signal and ICAM-1 expression in rosacea. We show for the first time that quercetin interacted with p65 and ICAM-1 directly to alleviated inflammatory and vascular dysfunction, suggesting quercetin is a novel, promising therapeutic candidate for rosacea.
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