医学
免疫组织化学
肿瘤科
肺癌
内科学
生物标志物
队列
表皮生长因子受体
癌症
腺癌
病理
生物
生物化学
作者
Arianna Marinello,Maria‐Rosa Ghigna,Julia Rotow,Tolulope Adeyelu,Giulio Metro,Mariana Brandão,Florian Guisier,I. Monnet,Hortense Gaultier De Saint Basile,Carlo Genova,Judith Raimbourg,Safae Terrisse,Karine Godefroy,Luca Toschi,Martina Mandarano,H. Doubre,Alessandro Russo,Alexander Valent,Abdul Rafeh Naqash,Ayesha Aijaz
出处
期刊：JAMA Oncology
[American Medical Association]
日期：2025-05-29
卷期号：11 (7): 762-770
标识
DOI：10.1001/jamaoncol.2025.1293
摘要
The results of this cohort study suggest that RET+ NSCLC tumors frequently express MET and TROP2, with MET positivity enriched vs RET-wt controls. Coexpression and biomarker dynamics highlight the need for membrane target screening and novel therapeutic strategies for this population.
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