Cascade enzymatic semiconducting polymer nanocomposites for NIR-II light-mediated photothermal-chemodynamic combinatorial therapy

-catalyzed reaction, thus achieving self-enhanced CDT through ˙OH burst, with concurrent mild hyperthermia (≤45 °C) for amplifying enzymatic activity and tumor-specific ROS accumulation. This NIR-II light-mediated PTT-CDT combinatorial therapy enables effective treatments of subcutaneous 4T1 tumors in mouse models.