Supramolecular Partners: Precision On/Off Neuromuscular Blockage for Prolonged Surgeries

The development of a long-acting neuromuscular blocking agent and its on-demand reversal is highly desired for prolonged surgeries. This viewpoint discussed the discovery of supramolecular partners, an imidazolium-based macrocycle (YW70271) and acyclic cucurbit[n]uril (WY22051), for ultralong neuromuscular blockade and rapid reversal.