环丁烷
Negishi偶联反应
化学
芳基
戒指(化学)
立体化学
碳纤维
碳原子
试剂
有机化学
烷基
环丁烷
数学
算法
复合数
作者
Min Yan,Qiang Zhou,Ping Lü
标识
DOI:10.1002/anie.202218008
摘要
Cyclobutenones provide a straightforward four-carbon ring platform for further structural elaborations in that every carbon atom of the ring could be potentially functionalized. We report here a nickel catalyzed enantioconvergent Negishi coupling of 4-iodocyclobutenones with an array of aryl or alkenyl zinc reagents to access enantioenriched 4-substituted cyclobutenones, from which a modular approach to the synthesis of 1,2,3,4-tetrasubstituted cyclobutanes was demonstrated.
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