秀丽隐杆线虫
自噬
生物
激酶
先天免疫系统
细胞生物学
调节器
丝裂原活化蛋白激酶
基因
细胞凋亡
免疫系统
遗传学
作者
Marian Chuang,Andrew Chisholm
出处
期刊:Apoptosis
[Springer Nature]
日期:2013-11-16
卷期号:19 (2): 392-397
被引量:10
标识
DOI:10.1007/s10495-013-0943-2
摘要
The death associated protein kinases (DAPK) are a phylogenetically widespread family of calcium-regulated serine/threonine kinases, initially identified from their roles in apoptosis. Subsequent studies, principally in vertebrate cells or models, have elucidated the functions of the DAPK family in autophagy and tumor suppression. Invertebrate genetic model organisms such as Drosophila and C. elegans have revealed additional functions for DAPK and related kinases. In the nematode C. elegans, the sole DAPK family member DAPK-1 positively regulates starvation-induced autophagy. Genetic analysis in C. elegans has revealed that DAPK-1 also acts as a negative regulator of epithelial innate immune responses in the epidermis. This negative regulatory role for DAPK in innate immunity may be analogous to the roles of mammalian DAPK in inflammatory responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI