神经退行性变
返老还童
痴呆
老化
神经科学
医学
疾病
生物
老年学
病理
遗传学
出处
期刊:Nature
[Springer Nature]
日期:2016-11-01
卷期号:539 (7628): 180-186
被引量:789
摘要
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.
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