» DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF LINEAR TETRAPEPTIDE D-Ala-L-(Gly-Val-Val) (AGVV)

A rational designing of the linear tetrapeptide D,Ala,L,(Gly,Val,Val) (AGVV) was done and was synthesi zed by solution phase peptide synthesis. The method includes synthesis of the tetrapeptide AGVV by using ethyl,3,dimethylami nopropylcarbodiimide (EDC) as a coupling reagent and triethylamine (TEA) as the base. The molecular docking studies of the designed tetrapeptide AGVV was carried out by using Molegro Virtual Docker software for anticancer properties. The synthesized compound was characterized by FT,IR, 1 H,NMR and Mass spectral data and was evaluated for antioxidant and anthelmintic activities. The linear tetrapeptide