光热治疗
乙二醇
药物输送
纳米颗粒
纳米技术
生物相容性
PEG比率
自愈水凝胶
体内
按需
材料科学
药品
生物利用度
化学
高分子化学
药理学
有机化学
医学
财务
经济
生物技术
生物
多媒体
计算机科学
作者
Xing Wang,Changping Wang,Yitong Wang,Qiang Zhang,Yiyun Cheng
标识
DOI:10.1021/acs.chemmater.6b05192
摘要
Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects. Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-photothermal therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π–π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-photothermal therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases.
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