医学
氟胞嘧啶
药品
抗真菌
白霉素类
抗真菌药
药代动力学
两性霉素B
药理学
广谱
抗真菌药
重症监护医学
卡斯波芬金
皮肤病科
组合化学
化学
作者
Jeniel E. Nett,David R. Andes
标识
DOI:10.1016/j.idc.2015.10.012
摘要
The currently available antifungal therapies vary significantly in terms of spectrum of activity, pharmacologic properties, toxicity, and potential for drug–drug interactions. This article provides a history of antifungal development and discusses the characteristics of individual drugs and drug classes, including the amphotericin B formulations, the triazoles, the echinocandins, and flucytosine. For each drug, the clinically relevant pharmacokinetics are reviewed, the spectrum of activity described, and the Food and Drug Administration–approved clinical indications examined. Antifungal side-effects, therapeutic drug monitoring, and drug–drug interactions are summarized. The variations among different formulations are highlighted.
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