Easy Access to a Library of Alkylindoles: Reductive Alkylation of Indoles with Carbonyl Compounds and Hydrosilanes under Indium Catalysis

Abstract By applying carbonyl compounds as sources of alkyl groups to the indium‐catalyzed reductive alkylation of indoles, a reliable and practical method capable of offering a wide range of alkylindoles with structural diversity has been developed. An important feature of this method is that the loading of the indium catalyst can be reduced by more than that of the original alkyne‐based system. magnified image