Determination and characterization of solubility of baicalin.

Objective:To understand the solubility of baicalin.Methods:Using HPLC to determine the solubility of baicalin in various solvents to study the influence of the temperature,pH,Surfactant to their solubility,using the solubility parameter theory to explore the theory of its solubility properties and to Characterize its Solubility.Results:Baicalin is almost insoluble in water areas;solubility increase as the temperature and pH raising,and the process of solubility is endothermic,the solubility is a good linear relationship of equation with the temperature.It can be used to predict the solubility of baicalin in setting temperature;Tween 80 has solubilization on baicalin;the solubility of baicalin in various solvents agree with results of the dissolution properties of baicalin using parameter of solubility.Conclusions:Baicalin is poor in water-soluble and fat-soluble,but the nature of the solubility of baicalin can chang with heating up,adjusting pH,and addition of surfactant.the solubility parameter theory can be used to characterize the solubility of baicalin.