Adverse Drug Reactions Induced by Statins:Analysis of Literature

OBJECTIVE:To discuss the regular patterns and characteristics of the adverse drug reactions(ADRs)induced by statins and to provide guidance for its rational use in the clinic.METHODS:A total of 19 ADR cases induced by statins reported domestically during the period 2000～2005 were classified and analyzed statistically.RESULTS:ADRs were mostly seen in the toxic reactions of muscle,followed by toxic reactions of liver and other adverse reactions such as nervous system reaction,pain in joints,allergies,etc.CONCLUSIONS:Indications of medication should be strictly controlled,dosage and drug combination types should be standardized,the clinical and biochemical indicators of patients should be closely monitored so as to ensure medication safety and reduce the incidence of adverse reactions.