PURPOSE: To evaluate the effectiveness of orthokeratology (Ortho-K) for treatment of myopia in youngths. METHODS: 110 eyes of 56 young peoples with myopia received Ortho-K were studied. The patients were divided into 3 groups according to preoperative diopters. No. I: -1.00(-)-3.00 D, No. II: -3.25(-)-6.00 D, NO. III: -6.25(-)-7.50 D. The uncorrected visual acuities, residual diopters and corneal refractive powers at various time of three months after the operation were statistically analyzed and compared with that of preoperation. Correlation analysis and linear regression analysis were performed between the corneal refractive reduction (X) and clinical refractive reduction (Y) after 3 months of the operation. RESULTS: In 110 eyes, the uncorrected visual acuities in the first day, first week, first month, second month and third month after operation were significantly improved than that of the preoperation (P < 0.01). The mean residual diopters were significantly reduced than that of preoperation (P < 0.01). The mean refractive powers of cornea were significantly decreased than that of the preoperative (P < 0.01). There was significant correlation between the corneal refractive reduction and clinical refractive reduction. (r = 0.3181, P < 0.001). CONCLUSION: Orthokeratology is a safe and effective therapeutic method for treatment of myopia in youngths. The long term effect of Orthokeratology need further observation.