Curative effects of bencycloquidium on allergic rhinitis in rats

AIM To investigate the curative effects and its mechanism of bencycloquidium on the allergic rhinitis(AR)in rats.METHODS The rat model of allergic rhinitis were induced by ovalbumin(Ova)and Al(OH)_3.Sixty rats were randomly derided into model group,bencycloquidium high medium and low doses groups,beclomethasone group,and vehicle group(each group including 10 rats).After 2 weeks of intranasal administration,the symptoms and morphological features of nasal mucosa of each rat were observed,unilateral nasal secretion of each rat was weighed,and Ova-specific IgE in serum and nasal seretion of each rat were assayed.RESULTS Compared with the vehicle group,the nasal symptoms scale,nasal secretion weight,Ova- specific IgE levels in serum and nasal mucosa,and morphological changes scale of nasal mucosa of rats in the model group were all higher.Compared with the model group,the nasal symptoms of rats in each of the bencycloquidium treament groups showed remarkably relieved(P0.01),morphological changes of nasal mucosa in high and medium doses of bencycloquidium treatment groups appeared to be significantly alleviated (P0.01),Ova-specific IgE in serum and nasal mucosa and nasal secretion of rats in high dose of bencycloquidium treatment group revealed obviously decreased(P0.01).CONCLUSION Bencycloquidium administered intranasally is effective in treating AR,and the mechanism might be through decreasing the Ova- specific IgE.