Research progress about Animal Model of Intervertebral Disc Degeneration

Establishing and applying animal model of intervertebral disc degeneration is an important method to study intervertebral disc degeneration,as well as to provide good experimental carrier for repair research.Animal models were divided into two groups:induced models or spontaneous models.Intervertebral disc degeneration found in the induced group can result from changing biomechanic environment of intervertebral disc and damaging the structure of intervertebral disc.The later aften results from autonomous intervertebral disc degeneration.Although kinds of animal models have their own limitation in some extent,animal model will have more prospects in the study of intervertebral disc degeneration with the clearance of dependability and comparability between animal model and human intervertebral disc degeneration.This article reviews progress about establishement of related animal model.