Inhibitory effect of DMPP in the angiogenesis of chick embryo

Objective To investigate the role of 1,1-dimethyM-phenylpiperazinium(DMPP) in the angiogenesis of early chick embryo.Methods The chicken chorioallantoic membrane(CAM) and yolk sac membrane (YSM) were treated with 50μg/mL DMPP.The angiogenesis of CAM was observed visually.The vascular density and growth rate of YSM were examined by microscopy.Results DMPP obviously suppressed the angiogenesis of CAM and decreased the vascular density and growth rate of YSM.Conclusion DMPP exhibits an inhibitory effect on the angiogenesis of chicken embryo.