Biosynthesis regulation and drug development for human ether-a-go-go related gene potassium channel:research advances

Human ether-a-go-go related gene(hERG) encodes α subunit of Ikr potassium channel which plays an essential role in Ⅲ phase repolarization of action potential.The expression and / or function of hERG channel could be influenced by mang factors,such as diverse drugs,low temperature or low K+,which may cause the QT interval prolongation,torsade de points and even sudden cardiac death.Therefore,the research of hERG potassium channel has significance for guiding development of new drugs and individualized treatment of arrhythmia.The hERG potassium channels as anti-arrhythmic drug treatment target which plays an important roles in new drugs safety test and development.This review summarizes recent progresses of structure and functions of hERG channel,the biosynthesis process of hERG potassium channel and regulatory elements,relationship between hERG potassium channel and long QT syndrome,and treatment for abnormal expression of hERG channel,which provides reference and basis for in-depth study of hERG channel.