Diagnostic value of blood procalcitonin, white blood cell count, C reactive protein in early infection after cardiac surgery in adults

Objective To investigate diagnostic value of blood procalcitonin, white blood cell count, C reactive protein(CRP) in early infection after cardiac surgery in adults. Methods A total of 117 adult patients undergoing cardiopulmonary bypass heart operation in our hospital from October 2010 to December 2013 were selected as observation group, of which 39 with postoperative infection were enrolled as group A and 78 without postoperative infection were enrolled as group B. Meanwhile, 117 healthy persons were selected as the control group. All the people underwent serum procalcitonin detection, white blood cell count, C reactive protein detection. Changes of relevant indexes at different time points(preoperative, postoperative 1 d, postoperative 2 d, postoperative 3 d) were compared between groups. Relevant operation indications were analyzed in the observation group. Results Blood procalcitonin,white blood cell count and CRP 3 d after operation in the observation group were higher than those in the control group. Blood procalcitonin, white blood cell count and CRP at postoperative increased significantly in group B, reached the highest at postoperative 1 d, and decreased significantly at postoperative 2 d. Blood procalcitonin, white blood cell count, CRP at postoperative increased significantly in group A, reached the highest at postoperative 3 d, which were higher than group B at postoperative, postoperative 1 d, 2 d, 3 d. Serum procalcitonin in patients with moderate infection were higher than those with mild infection, and serum procalcitonin in patients with severe infection were higher than those with mild infection and moderate infection. Operation time, cardiopulmonary bypass time, blocking time in group A were significantly longer than group B(P0.05). Postoperative infection had significant positive correlation with blood procalcitonin, white blood cell count and CRP(P0.05). Conclusion Blood procalcitonin, white blood cell count, CRP can be used as effective indexes in the diagnosis of early infection after cardiac surgery in adults.