Integration of Metabolism in Man and His Microbiome in Critical Conditions

The paper postulates whether the phenomenon of integration of metabolism in man and his microbiome exists. The author’s previously hypothesized fact that small molecules from microbes are involved in human homeostasis [1, 2] has found confirmation in subsequent experimental and clinical studies. The interactions of bacterial metabolites with the human body, which are natural and harmonious in health, are shown to become distorted in different diseases, which may be present in critical conditions at the most and the worsening disintegration results in multiple organ dysfunction and a fatal outcome. Thus, the performed investigations have established that there is a relationship between the severity and outcome of disease and the metabolic profile of low-molecular-weight aromatic compounds from microbes in the patient’s blood and that there are key molecules that are involved in the integrative interaction with human cells among the exometabolites of aerobic and anaerobic bacteria (the main representatives of the human microbiota); the mechanisms of this interaction at the cellular and subcellular levels have been studied. In the author’s opinion, a study of integration mechanisms and the role of microbial aromatic metabolites (MAM) and a search for MAM-oriented therapeutic methods open up new avenues to improve the results of patient treatment in different fields of medicine and mainly in reanimatology. Key words: critical conditions, metabolism, microbial aromatic metabolites, phenylcarboxylic acids, sepsis, intestinal microbiome.