适体
体内
核酸
材料科学
血管生成
体外
再生(生物学)
纳米技术
组织工程
纳米工程
移植
细胞生物学
癌症研究
新生血管
生物
生物医学工程
分子生物学
生物化学
医学
内科学
生物技术
作者
Dan Zhao,Mengting Liu,Jiajie Li,Dexuan Xiao,Shuanglin Peng,Qing He,Yue Sun,Qirong Li,Yunfeng Lin
标识
DOI:10.1021/acsami.1c08565
摘要
In a search for a solution to large-area soft and hard tissue defects, whether or not tissue regeneration or tissue-substitutes transplantation is used, the problems with angiogenesis need to be solved urgently. Thus, a new and efficient proangiogenic approach is needed. Nanoengineering systems have been considered one of the most promising approaches. In this study, we modify the tetrahedral framework nucleic acid (tFNA) for the first time with two different angiogenic DNA aptamers to form aptamer–tFNA nanostructures, tFNA–Apt02 and tFNA–AptVEGF, and the effects of them on angiogenesis both in vitro and in vivo are investigated. We develop new nanomaterials for enhancing angiogenesis to solve the problem of tissue engineering vascularization and ischemic diseases. The results of our study confirm that tFNA–Apt02 and tFNA–AptVEGF has a stronger ability to accelerate endothelial cell proliferation and migration, tubule formation, spheroid sprouting, and angiogenesis in vivo. We first demonstrate that the engineered novel tFNA–Apt02 and tFNA–AptVEGF have promoting effects on angiogenesis both in vitro and in vivo and provide a theoretical basis and opportunity for their application in tissues engineering vascularization and ischemic diseases.
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