Probiotics, their Health Benefits and Applications for Development of Human Health: A Review

Gastrointestinal microbial flora plays a major role in health of host. The person with the healthy digestive system is the indication of proper health. Probiotics bacteria are live nonpathogenic microorganism which has beneficial effects on host gastrointestinal tract which is mentioned in articles viz. Recent Advances in Pharmaceutical Approaches to Colon Specific Drug Delivery. Optimum population of probiotics bacteria are essential for the maintenance and effective functioning of the digestive system. Hence probiotics are the good therapeutic agents for the various abnormal conditions of gastrointestinal tract such as inflammatory bowel disease, chrohn’s disease, colon cancer etc. Probiotic micro biota also fights against pathogenic infections of GIT such as H. pylori infection by production of some antimicrobial chemical secretions such as bacteriocin. Recent studies and innovations and studies found that the probiotic bacteria are beneficial in the prevention and curative treatment of various disease and disorders like colorectal cancer, infection of urinary tract (UTI), allergic condition, cardiovascular disorders and depressive disorders. Probiotics are administered as nutraceutical products in the form of both conventional pharmaceutical dosage forms and traditional non-conventional food products, inclusion complexes with cyclodextrins effectively, sustained release tablets by solid dispersion technology etc. Probiotics are significantly gaining popularity due their wide application and safety. This paper presents the comprehensive review on the probiotics profile along with its some therapeutic applications, delivery approaches and current aspects.  Keywords: Probiotics, mechanisms, Health benefits, cardiovascular disorders, safety, colon targeted drug delivery system.