神经生长因子
脊髓损伤
神经保护
细胞凋亡
体内
中枢神经系统
再生(生物学)
PI3K/AKT/mTOR通路
药理学
巨噬细胞
蛋白激酶B
病变
药物输送
医学
脊髓
神经科学
细胞生物学
生物
化学
病理
体外
内科学
受体
有机化学
生物技术
生物化学
作者
Nan Xia,Zhanshan Gao,Hengshuo Hu,Daoyong Li,Chuanjie Zhang,Xifan Mei,Chao Wu
标识
DOI:10.1177/08853282211025912
摘要
Spinal cord injury (SCI) is an extremely destructive central nervous system lesion. Studies have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce the desired effect due to its stability in the body and is difficulty in passing through the blood-brain barrier. In this study, we prepared nanovesicles derived from macrophage membrane encapsulating NGF (NGF-NVs) as a drug carrier for the treatment of SCI. Cell experiments showed that NGF-NVs were effectively taken up by PC12 cells and inhibited neuronal apoptosis. In vivo imaging experiments, a large quantity of NGF was delivered to the injured site with the aid of the good targeting of NVs. In animal experiments, NGF-NVs improved the survival of neurons by significantly activating the PI3K/AKT signaling pathway and had good behavioral and histological recovery effects after SCI. Therefore, NVs are a potential drug delivery vector for SCI therapy.
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